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Stable Cell Lines

Stable cell lines are one of the most used tools in drug discovery, toxicity testing, and basic research. Long-term stable expression of a gene of interest is usually achieved by transfection or viral transduction of a vector containing the expression cassette of the gene of interest together with a selection marker (antibiotics or fluorescent proteins). In contrast to transient expression, stable cell lines offer reproducible results for assay studies in drug discovery and development.

AS ONE International, Inc. provides stable cell lines with constitutive expression of a wide variety of genes, including GPCRs, ion channels, proteases and kinases as well as various other enzymes, transmembrane proteins and adhesion molecules. These cell lines are designed for High Content Screening (HCS) methodologies and have been fully tested and validated for these purposes. Here are some examples of these stable cell lines:

 

See all cell lines and primary cells