Recombinant Human ACE2 Protein (Fc Tag)

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SKU: PKSR030492 Research Area: Applications:

Description

●Background:Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency.
 
ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
 
●Protein Construction:Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a Fc tag at the C-terminus.
 
●Synonym:Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
 
●Sequence:Gln18-Ser740
 
●Fusion tag:C-Fc
 
●Accession:Q9BYF1
 
●Species:Human
 
●Expressed Host:Human Cells
 
●Purity:> 95 % as determined by reducing SDS-PAGE.
 
●Endotoxin:< 1.0 EU per µg as determined by the LAL method.   ●Mol Mass:110.5 kDa   ●AP Mol Mass:110-140 kDa   ●Formulation:Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.

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