Osteoclast Culture Kit V-2 (Rat)

$1,131.43

SKU: PMC-OSC12-COS Research Area: Applications:

Description

Osteoclast Culture Kit includes cryopreserved osteoclast precursor (OCP) cells from bone marrow and culture medium containing M-CSF and RANKL for researchers studying osteoporosis, bone reabsorption, or other bone metabolism disorders.?Osteoclast cells form from a hematopoietic stem cells called monocytes. Osteoclasts resorb bone by attaching to the bone surface and lowering the surrounding pH to an acidic level of around 4.5. The bone mineral is then solubilized and the collagen degraded. Osteoclast differentiation and function is controlled primarily by Macrophage Colony-Stimulating Factor (M-CSF) and Receptor for Activation of Nuclear Factor Kappa B Ligand (RANKL). The absence of NF-Kappa B leads to the bone disease osteopetrosis and the absence of M-CSF results in the arrest of differentiation in the pre-osteoclast stage. B-Bridge???s Osteoclast Culture Kit includes cryopreserved osteoclast precursor (OCP) cells from bone marrow and culture medium containing M-CSF and RANKL for researchers studying osteoporosis, bone reabsorbtion, or other bone metabolism disorders.

Title Type Size
PMC-OSC12-COS_Protocol application/pdf 121 KB

Reviews

There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.