Apoptosis

Apoptosis is a process of programmed cell death that occurs in multicellular organisms. Apoptosis plays critical roles in both heath (e.g. development and immunity) and disease such as cancer and neurodegeneration. Accompanied by complex cascades of intracellular events, apoptosis is characterized by several biochemical features including cell shrinkage, membrane blebbing, chromosome condensation, nuclear fragmentation, DNA laddering and the eventual engulfment of the cell by phagosomes. Key apoptotic molecules include Bcl-2 family proteins, caspases and nucleases. Apoptosis can be initiated via several mechanisms including trophic factor withdrawal, ligation of pro-apoptotic transmembrane receptors, or the activities of cytotoxic immune cells.

AS ONE INTERNATIONAL offers a wide selection of reagents such as antibodies, proteins, assay kits for studying apoptosis.

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