Mechanical stretch has been demonstrated to be of great importance in regulating tissue morphogenesis, physiological homeostasis, and pathogenic processes in endothelial, epithelial, and smooth muscle cells. In vitro studies of cellular behaviors under external dynamic directional stretch that mimics in vivo conditions have helped reveal novel mechanobiological phenomena spanning from cellular phenotypes such as morphogenesis, proliferation, differentiation, and inflammation to gene expression profiles.
AS ONE INTERNATIONAL offers high-performance mechanical cell strain instruments and cell culture chambers that allow researchers to explore the impact of mechanical cell strain on cells in culture through simulating a natural dynamic physiological environment. Microscope-mountable instruments enable real-time observations of cells experiencing uni-axial or bi-axial dynamic or static strain. Bench top uni-axial mechanical cell strain instruments are ideal for long duration studies, especially for investigating gene and protein expression or cytoskeletal rearrangement.